Name
Abstract | ||
|---|---|---|
This paper proposes a model in terms of metabolic P graphs of a few important processes occurring during the biological phase where the choice is made to begin again mitosis or to arrest it. The cellular processes during this phase turn out to be especially interesting in the case of DNA damage, which triggers a specific destruction of Cdc25A phosphatase. It has important implications to understand the role of cell cycle checkpoints and the mechanism(s) guiding the proliferation of UV-resistant tumored cells. The formalism of metabolic P graphs highlights the relevant information of the biological network dynamics, and the individuation of few parameters rules the basic mechanisms of Cdc25A degradation, involving a couple of important mitotic oscillators. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1007/11963516_24 | Workshop on Membrane Computing |
Keywords | Field | DocType |
dna damage,important mitotic oscillator,important implication,cdc25a phosphatase,biological phase,metabolic p graph,mp graph,cdc25a degradation,biological network dynamic,uv-resistant tumored cell,important process,oscillations,cell cycle checkpoint,biological network | Graph,Mitosis,Biological network,Computer science,Cell biology,Biological phase,DNA damage,Bioinformatics,CDC25A,Cell cycle checkpoint,Membrane computing | Conference |
Volume | ISSN | ISBN |
4361 | 0302-9743 | 3-540-69088-3 |
Citations | PageRank | References |
6 | 0.56 | 10 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Giuditta Franco | 1 | 136 | 18.34 |
| Pietro Hiram Guzzi | 2 | 547 | 65.85 |
| Vincenzo Manca | 3 | 562 | 59.74 |
| Tommaso Mazza | 4 | 123 | 14.49 |