Title
Form follows function: model-driven engineering for clinical trials
Abstract
We argue that, for certain constrained domains, elaborate model transformation technologies--implemented from scratch in general-purpose programming languages--are unnecessary for model-driven engineering; instead, lightweight configuration of commercial off-the-shelf productivity tools suffices. In particular, in the CancerGrid project, we have been developing model-driven techniques for the generation of software tools to support clinical trials. A domain metamodel captures the community's best practice in trial design. A scientist authors a trial protocol, modelling their trial by instantiating the metamodel; customized software artifacts to support trial execution are generated automatically from the scientist's model. The metamodel is expressed as an XML Schema, in such a way that it can be instantiated by completing a form to generate a conformant XML document. The same process works at a second level for trial execution: among the artifacts generated from the protocol are models of the data to be collected, and the clinician conducting the trial instantiates such models in reporting observations--again by completing a form to create a conformant XML document, representing the data gathered during that observation. Simple standard form management tools are all that is needed. Our approach is applicable to a wide variety of information-modelling domains: not just clinical trials, but also electronic public sector computing, customer relationship management, document workflow, and so on.
Year
DOI
Venue
2011
10.1007/978-3-642-32355-3_2
FHIES
Keywords
DocType
Citations 
domain metamodel,XML Schema,trial execution,document workflow,conformant XML document,simple standard form management,model-driven engineering,trial protocol,clinical trial,trial design,customer relationship management
Conference
2
PageRank 
References 
Authors
0.42
11
6
Name
Order
Citations
PageRank
Jim Davies167380.95
Jeremy Gibbons246942.73
Radu Calinescu390563.01
Charles Crichton41019.36
Steve Harris5557.37
Andrew Tsui6203.03