Name
Title | ||
|---|---|---|
Comparative molecular field analysis of non-steroidal aromatase inhibitors related to fadrozole. |
Abstract | ||
|---|---|---|
A series of non-steroidal inhibitors of aromatase, structurally related to fadrozole (2), was investigated with the aim of developing a 3D QSAR model using the Comparative Molecular Field Analysis (CoMFA) technique. The alignment of the molecules was performed following two approaches (atom-by-atom and field fit), both starting from an initial hypothesis of superimposition of fadrozole to a steroidal inhibitor (3). From a number of CoMFA models built with different characteristics, one was recognized as the most statistically relevant; this one is discussed in detail. The features of the 3D QSAR model are consistent with those of other 3D and QSAR models of aromatase and its inhibitors. |
Year | DOI | Venue |
|---|---|---|
1996 | 10.1007/BF00124467 | Journal of computer-aided molecular design |
Keywords | Field | DocType |
3D QSAR,Cytochrome P-450,Antiestrogens | Quantitative structure–activity relationship,Field analysis,Aromatase,Chemistry,Fadrozole,Stereochemistry | Journal |
Volume | Issue | ISSN |
10 | 1 | 0920-654X |
Citations | PageRank | References |
3 | 0.46 | 1 |
Authors | ||
1 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Maurizio Recanatini | 1 | 18 | 6.57 |