Name
Title | ||
|---|---|---|
Promoter complexity and tissue-specific expression of stress response components in Mytilus galloprovincialis, a sessile marine invertebrate species. |
Abstract | ||
|---|---|---|
The mechanisms of stress tolerance in sessile animals, such as molluscs, can offer fundamental insights into the adaptation of organisms for a wide range of environmental challenges. One of the best studied processes at the molecular level relevant to stress tolerance is the heat shock response in the genus Mytilus. We focus on the upstream region of Mytilus galloprovincialis Hsp90 genes and their structural and functional associations, using comparative genomics and network inference. Sequence comparison of this region provides novel evidence that the transcription of Hsp90 is regulated via a dense region of transcription factor binding sites, also containing a region with similarity to the Gamera family of LINE-like repetitive sequences and a genus-specific element of unknown function. Furthermore, we infer a set of gene networks from tissue-specific expression data, and specifically extract an Hsp class-associated network, with 174 genes and 2,226 associations, exhibiting a complex pattern of expression across multiple tissue types. Our results (i) suggest that the heat shock response in the genus Mytilus is regulated by an unexpectedly complex upstream region, and (ii) provide new directions for the use of the heat shock process as a biosensor system for environmental monitoring. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1371/journal.pcbi.1000847 | PLOS COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
cluster analysis,gene network,stress response,gene expression profiling,comparative genomics,principal component analysis,heat shock,conserved sequence,analysis of variance,transcription factor binding site,sequence alignment,marine invertebrate,heat shock response,environmental monitoring | Conserved sequence,Mytilus,DNA binding site,Biology,Heat shock,Regulation of gene expression,Comparative genomics,Bioinformatics,Genetics,Gene regulatory network,Gene expression profiling | Journal |
Volume | Issue | ISSN |
6 | 7 | 1553-7358 |
Citations | PageRank | References |
0 | 0.34 | 7 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Chrysa Pantzartzi | 1 | 0 | 0.34 |
| Elena Drosopoulou | 2 | 0 | 0.34 |
| Minas Yiangou | 3 | 0 | 0.34 |
| Ignat Drozdov | 4 | 6 | 0.78 |
| Sophia Tsoka | 5 | 172 | 19.38 |
| Christos A. Ouzounis | 6 | 879 | 200.77 |
| Zacharias G Scouras | 7 | 1 | 1.06 |