Title
Automated macular pathology diagnosis in retinal OCT images using multi-scale spatial pyramid and local binary patterns in texture and shape encoding.
Abstract
We address a novel problem domain in the analysis of optical coherence tomography (OCT) images: the diagnosis of multiple macular pathologies in retinal OCT images. The goal is to identify the presence of normal macula and each of three types of macular pathologies, namely, macular edema, macular hole, and age-related macular degeneration, in the OCT slice centered at the fovea. We use a machine learning approach based on global image descriptors formed from a multi-scale spatial pyramid. Our local features are dimension-reduced local binary pattern histograms, which are capable of encoding texture and shape information in retinal OCT images and their edge maps, respectively. Our representation operates at multiple spatial scales and granularities, leading to robust performance. We use 2-class support vector machine classifiers to identify the presence of normal macula and each of the three pathologies. To further discriminate sub-types within a pathology, we also build a classifier to differentiate full-thickness holes from pseudo-holes within the macular hole category. We conduct extensive experiments on a large dataset of 326 OCT scans from 136 subjects. The results show that the proposed method is very effective (all AUC>0.93).
Year
DOI
Venue
2011
10.1016/j.media.2011.06.005
Medical Image Analysis
Keywords
Field
DocType
Computer-aided diagnosis (CAD),Optical Coherence Tomography (OCT),Macular pathology,Multi-scale spatial pyramid (MSSP),Local binary patterns (LBP)
Computer vision,Histogram,Optical coherence tomography,Macular edema,Pattern recognition,Computer science,Support vector machine,Local binary patterns,Computer-aided diagnosis,Macular degeneration,Artificial intelligence,Macular hole
Journal
Volume
Issue
ISSN
15
5
1361-8415
Citations 
PageRank 
References 
26
1.22
16
Authors
6
Name
Order
Citations
PageRank
Yu-Ying Liu1353.04
Mei Chen241836.25
ishikawa351530.86
Gadi Wollstein4576.02
Joel S Schuman5638.75
James M. Rehg65259474.66