Name
Title | ||
|---|---|---|
Computational multiscale modeling in the IUPS Physiome Project: modeling cardiac electromechanics |
Abstract | ||
|---|---|---|
We present a computational modeling and numerical simulation framework that enables the integration of multiple physics and spatiotemporal scales in models of physiological systems. This framework is the foundation of the IUPS (International Union of Physiological Sciences) Physiome Project. One novel aspect is the use of CellML, an annotated mathematical representation language, to specify model- and simulation-specific equations. Models of cardiac electromechanics at the cellular, tissue, and organ spatial scales are outlined to illustrate the development and implementation of the framework. We quantify the computational demands of performing simulations using such models and compare models of differing biophysical detail. Applications to other physiological systems are also discussed. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1147/rd.506.0617 | IBM Journal of Research and Development |
Keywords | DocType | Volume |
numerical simulation framework,cardiac electromechanics,annotated mathematical representation language,IUPS Physiome Project,computational modeling,computational demand,biophysical detail,computational multiscale modeling,Physiome Project,physiological system,Physiological Sciences,International Union | Journal | 50 |
Issue | ISSN | Citations |
6 | 0018-8646 | 5 |
PageRank | References | Authors |
1.15 | 4 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| D. Nickerson | 1 | 5 | 1.49 |
| Martyn P. Nash | 2 | 133 | 23.64 |
| P. Nielsen | 3 | 37 | 13.06 |
| Nicolas Smith | 4 | 35 | 6.70 |
| Hunter P J | 5 | 1352 | 177.64 |