Name
Title | ||
|---|---|---|
Gene Expression and Pathway Analysis of Quiescent CD8+ T Cells from Liver Cancer, Liver Sinusoid and Peripheral Blood - Study on Toxicogenomics and Prevention Targeting |
Abstract | ||
|---|---|---|
The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/BIBE.2011.18 | BIBE |
Keywords | Field | DocType |
liver sinusoid,quiescent gene,liver cancer,liver tumor,tumor tissue,gene expression,tumor microenvironment,peripheral blood,sinusoidal structure,quiescent status,pathway analysis,tumor cell,drug targeting,immune response,cd8 t cell,toxicology,biochemistry,cancer,immune system,genetics,proteins,molecular biophysics,toxicogenomics | Tumor microenvironment,Toxicogenomics,CD8,Liver tumor,Biology,Cell biology,Immune system,Cytotoxic T cell,Liver sinusoid,T cell | Conference |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zhaohui Wang | 1 | 7 | 7.58 |
| Hongliang Hu | 2 | 0 | 0.34 |
| Jie Zheng | 3 | 5 | 8.33 |
| Biaoru Li | 4 | 0 | 0.34 |