Name
Abstract | ||
|---|---|---|
Cerebral white matter lesions are associated with poorer motor performances in the elderly, but the role of gray matter atrophy remains largely unknown. We investigated the cross-sectional relation between brain regional gray matter volumes and walking speed over 6m in the 3C-Dijon study, a large population-based study of community-dwelling persons aged 65years and over (N=1623). Regional gray matter volumes were obtained using an automated anatomical labeling parcellation method. Multivariable analyses were performed using a semi-Bayes approach. After adjustment for potential confounders, persons who walked slower had a smaller volume of basal ganglia (regression coefficient [β]=0.054, standard error [SE]=0.028, p=0.05). In more detailed analyses, the volume of the caudate nucleus had a preponderant role on this association (β=0.049, SE=0.019, p=0.009), and walking speed decreased progressively with the volume of the caudate nucleus (p for linear trend<0.001). These results underline the role of gray matter subcortical structures, in particular of the caudate nucleus, in the age-related decline of motor performances among community-dwelling elderly subjects. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2012.01.102 | NeuroImage |
Keywords | Field | DocType |
BMI,MMSE,TIV,WMLs | Caudate nucleus,Developmental psychology,Population,Anatomy,Gait,Psychology,Cerebral white matter,Atrophy,Basal ganglia,Preferred walking speed | Journal |
Volume | Issue | ISSN |
60 | 2 | 1053-8119 |
Citations | PageRank | References |
0 | 0.34 | 6 |
Authors | ||
10 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Julien Dumurgier | 1 | 0 | 0.34 |
| Fabrice Crivello | 2 | 49 | 3.40 |
| B Mazoyer | 3 | 72 | 11.65 |
| Ismaïl Ahmed | 4 | 0 | 0.68 |
| Béatrice Tavernier | 5 | 0 | 0.34 |
| David Grabli | 6 | 0 | 1.01 |
| Chantal François | 7 | 0 | 0.68 |
| Nathalie Tzourio-Mazoyer | 8 | 63 | 3.95 |
| Christophe Tzourio | 9 | 4 | 1.64 |
| Alexis Elbaz | 10 | 0 | 0.34 |