Title
Measuring fMRI reliability with the intra-class correlation coefficient.
Abstract
The intra-class class correlation coefficient (ICC) is a prominent statistic to measure test–retest reliability of fMRI data. It can be used to address the question of whether regions of high group activation in a first scan session will show preserved subject differentiability in a second session. With this purpose, we present a method that extends voxel-wise ICC analysis. We show that voxels with high group activation have more probability of being reliable, if a subsequent session is performed, than typical voxels across the brain or across white matter. We also find that the existence of some voxels with high ICC but low group activation can be explained by stable signals across sessions that poorly fit the HRF model. At a region of interest level, we show that our voxel-wise ICC calculation is more robust than previous implementations under variations of smoothing and cluster size. The method also allows formal comparisons between the reliabilities of given brain regions; aimed at establishing which ROIs discriminate best between individuals. The method is applied to an auditory and a verbal working memory task. A reliability toolbox for SPM5 is provided at http://brainmap.co.uk.
Year
DOI
Venue
2009
10.1016/j.neuroimage.2008.12.035
NeuroImage
Keywords
Field
DocType
fMRI,Reliability,Intra-class correlation coefficient,Working memory,Auditory cortex
Voxel,Auditory cortex,Correlation coefficient,Developmental psychology,Statistic,Working memory,Psychology,Smoothing,Region of interest,Intraclass correlation
Journal
Volume
Issue
ISSN
45
3
1053-8119
Citations 
PageRank 
References 
33
1.89
9
Authors
5
Name
Order
Citations
PageRank
Alejandro Caceres1362.33
Deanna L Hall2331.89
Fernando O Zelaya3331.89
Steven C R Williams424524.98
Mitul A Mehta57612.54