Paper Info
Title
Visant 4.0: Integrative Network Platform To Connect Genes, Drugs, Diseases And Therapies
Abstract
With the rapid accumulation of our knowledge on diseases, disease-related genes and drug targets, network-based analysis plays an increasingly important role in systems biology, systems pharmacology and translational science. The new release of VisANT aims to provide new functions to facilitate the convenient network analysis of diseases, therapies, genes and drugs. With improved understanding of the mechanisms of complex diseases and drug actions through network analysis, novel drug methods (e. g., drug repositioning, multi-target drug and combination therapy) can be designed. More specifically, the new update includes (i) integrated search and navigation of disease and drug hierarchies; (ii) integrated disease-gene, therapy-drug and drug-target association to aid the network construction and filtering; (iii) annotation of genes/drugs using disease/therapy information; (iv) prediction of associated diseases/therapies for a given set of genes/drugs using enrichment analysis; (v) network transformation to support construction of versatile network of drugs, genes, diseases and therapies; (vi) enhanced user interface using docking windows to allow easy customization of node and edge properties with build-in legend node to distinguish different node type. VisANT is freely available at:http://visant.bu.edu.
Year
DOI
Venue
2013
10.1093/nar/gkt401
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
genes,drug discovery,internet,drug therapy
Systems pharmacology,Drug discovery,Disease,Drug repositioning,Biology,Translational science,Systems biology,Computational biology,Bioinformatics,Genetics,User interface,Drug
Journal
Volume
Issue
ISSN
41
W1
0305-1048
Citations 
PageRank 
References 
17
0.95
13
Authors
8
Name
Order
Citations
PageRank
Zhenjun Hu133924.50
Yi-Chien Chang2734.44
Yan Wang3181.91
Chia-Ling Huang4895.79
Yang Liu5170.95
Feng Tian6170.95
Brian Granger7171.62
Charles Delisi848941.96