Paper Info
Title
The Assembly of the Human and Mouse Genomes
Abstract
Paired-read shotgun sequencing of a genome consists of randomly sampling segments of a fixed length, say 10,000 base pairs (10Kbp), and directly determining a “read” of 500 to 700bp at the two ends of each segment with an automated DNA sequencing instrument. Reconstructing or “assembling” a very large genome from such a data set was considered impossible at the time Jim Weber and I proposed it for the Human Genome (2.9Gbp) in 1996. Critics claimed that the computation would involve an impossible amount of computer time, that the size and repetitiveness of the genome would confound all attempts at assembly should sufficient computer efficiency be achieved, and that even if an assembly were produced it would be of an extremely poor quality and partial nature.
Year
DOI
Venue
2002
10.1007/3-540-45655-4_1
COCOON
Keywords
Field
DocType
mouse genomes,dna sequence,base pair,human genome
Genome,Shotgun sequencing,Discrete mathematics,Genome project,Computer science,DNA sequencing,Human genome,Bioinformatics,Computational biology,Cot analysis,Base pair
Conference
ISBN
Citations 
PageRank 
3-540-43996-X
0
0.34
References 
Authors
1
1
Name
Order
Citations
PageRank
Eugene Myers13164496.92