Title
Robust filtering of extended stochastic genetic regulatory networks with parameter uncertainties, disturbances, and time-varying delays
Abstract
This paper addresses robust H"~ filtering problem for a nonlinear genetic regulatory network (GRN), which is extended to include noise and disturbances, parameter uncertainties, and time-varying delays simultaneously. It is assumed that the nonlinear function that describes the feedback regulation satisfies the sector-bounded condition, the stochastic state perturbation is in the form of a scalar Brownian motion, and the time-varying delays enter into both the translation process and the feedback regulation process. To account for the unavoidable modeling errors and parameter fluctuations, the network parameters are assumed to be time-varying but norm-bounded values. We aim to estimate the true concentrations of mRNAs and proteins by designing a linear filter such that, for all admissible uncertainties, nonlinearities, stochastic perturbations and time delays, the dynamics of the filtering error is guaranteed to be robustly asymptotically stable in the mean square sense while achieving the prescribed H"~ disturbance attenuation level. By using the Lyapunov stability theory and Ito@? formula, sufficient conditions for the existence of the filter are obtained in the form of a linear matrix inequality (LMI). Then, explicit expressions for the desired filter gains are provided. Finally, a simulation example is given in order to illustrate the effectiveness of the proposed design procedure.
Year
DOI
Venue
2011
10.1016/j.neucom.2011.01.018
Neurocomputing
Keywords
Field
DocType
stochastic system,stochastic genetic regulatory network,nonlinear genetic regulatory network,parameter fluctuation,nonlinear function,time-varying delay,genetic regulatory network,nonlinear filtering,h ∞ filtering,network parameter,parameter uncertainty,feedback regulation,linear matrix inequality,linear filter,robust filtering,filter gain,feedback regulation process,brownian motion,model error,satisfiability,linear filtering,nonlinear filter
Nonlinear system,Linear filter,Control theory,Lyapunov stability,Filter (signal processing),Filtering problem,Brownian motion,Mathematics,Linear matrix inequality,Stability theory
Journal
Volume
Issue
ISSN
74
12-13
Neurocomputing
Citations 
PageRank 
References 
8
0.51
16
Authors
2
Name
Order
Citations
PageRank
Seyed Mohsen Mousavi1906.29
Vahid Johari Majd215415.51