Title
Stimulation of subthalamic nucleus inhibits emotional activation of fusiform gyrus.
Abstract
In patients with Parkinson’s disease, deep brain stimulation of the subthalamic nucleus is known to impair their ability to correctly identify facial expressions of negative emotions. This difficulty exists only when the stimulator is active. The reason for the impairment is unknown. To test the hypothesis that the stimulation itself is responsible, we used positron emission tomography to compare functional activations of brain regions in nine patients with Parkinson’s disease treated with surgically implanted electrodes into both subthalamic nuclei, and 22 healthy volunteers. Both groups viewed images with neutral or emotional content from Aarhus University’s standard Empathy Picture System (www.geday.net/eps) with 360 images of people in pleasant, unpleasant or neutral real-life situations, presenting either the situations or close-ups of the facial expressions of the people involved.
Year
DOI
Venue
2006
10.1016/j.neuroimage.2006.06.056
NeuroImage
Keywords
Field
DocType
Parkinson,Subthalamic nucleus (STN),Emotion,Facial expression,Fusiform gyrus
Empathy,Developmental psychology,Deep brain stimulation,Putamen,Neuroscience,Cognitive psychology,Psychology,Facial expression,Fusiform gyrus,Stimulus (physiology),Subthalamic nucleus,Stimulation
Journal
Volume
Issue
ISSN
33
2
1053-8119
Citations 
PageRank 
References 
0
0.34
2
Authors
3
Name
Order
Citations
PageRank
Jacob Geday100.34
Karen Ostergaard200.34
A GJEDDE3409.87