Name
Title | ||
|---|---|---|
Characterisation of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brain. |
Abstract | ||
|---|---|---|
Accurate quantification of PET imaging data is required for a useful interpretation of the measured radioactive tracer concentrations. The partial volume effect (PVE) describes signal dilution and mixing due to spatial resolution and sampling limitations, which introduces bias in quantitative results. In the present study we investigated the magnitude of PVE for volumes of interest (VOIs) in the rat brain and the effect of positron range. In simulated 11C-raclopride studies we examined the influence of PVE on time activity curves in striatal and cerebellar VOIs and binding potential estimation. The performance of partial volume correction (PVC) was studied using the region-based geometric transfer matrix (GTM) method including the question of whether a spatially variant point spread function (PSF) is necessary for PVC of a rat brain close to the centre of the field of view. Furthermore, we determined the effect of spillover from activity outside the brain. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2012.02.032 | NeuroImage |
Keywords | Field | DocType |
Positron emission tomography (PET),Rat brain imaging,Quantification,Partial volume effect,Partial volume correction | Nuclear medicine,Biomedical engineering,Voxel,Cognitive psychology,Psychology,Radioactive tracer,Positron emission tomography,Point spread function,Image resolution,Partial volume,Positron,Binding potential | Journal |
Volume | Issue | ISSN |
60 | 4 | 1053-8119 |
Citations | PageRank | References |
6 | 1.01 | 5 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Wencke Lehnert | 1 | 6 | 1.01 |
| Marie-Claude Gregoire | 2 | 17 | 3.82 |
| Anthonin Reilhac | 3 | 50 | 8.20 |
| Steven R. Meikle | 4 | 23 | 5.20 |