Paper Info
Title
Two forms of feedback inhibition determine the dynamical state of a small hippocampal network.
Abstract
Pyramidal cells in the hippocampus are part of a small neuronal network that performs computations on external input. The network consists of principal cells and various forms of feedback inhibition. Experimental evidence indicates at least two functionally distinct inhibitory feedback loops in the CA3 area of the hippocampus: (1) a loop in which O-LM interneurons project to the distal dendrites of pyramidal cells with synapses that have slow kinetics, and (2) a loop in which basket interneurons project to the somata of pyramidal cells with synapses that have fast kinetics. There is an interconnection between the two loops in the form of O-LM to basket interneuron inhibition and the configuration is further complicated by the presence of distinct propagation delays and short-term facilitation and depression of certain synapses in the two basic loops. In this study we investigated the consequences of various configurations of the circuit and modulations of the components of inhibition for the computation that the network can perform on its input.
Year
DOI
Venue
2009
10.1016/j.neunet.2009.07.015
Neural Networks
Keywords
Field
DocType
Hippocampus,CA3,Inhibition,Feedback loop,Covariance analysis,Pinsky and Rinzel pyramidal cell model
Pyramidal cell,Synapse,Mathematical optimization,Neuroscience,Feedback loop,Inhibitory postsynaptic potential,Artificial intelligence,Biological neural network,Interneuron,Time constant,Mathematics,Dendrite
Journal
Volume
Issue
ISSN
22
8
0893-6080
Citations 
PageRank 
References 
2
0.41
4
Authors
2
Name
Order
Citations
PageRank
Fleur Zeldenrust1143.08
Wytse J. Wadman2164.40