Paper Info
Title
Mapping directionality specific volume changes using tensor based morphometry: An application to the study of gyrogenesis and lateralization of the human fetal brain.
Abstract
Tensor based morphometry (TBM) is a powerful approach to analyze local structural changes in brain anatomy. However, conventional scalar TBM methods do not completely capture all direction specific volume changes required to model complex changes such as those during brain growth. In this paper, we describe novel TBM descriptors for studying direction-specific changes in a subject population which can be used in conjunction with scalar TBM to analyze local patterns in directionality of volume change during brain development. We also extend the methodology to provide a new approach to mapping directional asymmetry in deformation tensors associated with the emergence of structural asymmetry in the developing brain. We illustrate the use of these methods by studying developmental patterns in the human fetal brain, in vivo. Results show that fetal brain development exhibits a distinct spatial pattern of anisotropic growth. The most significant changes in the directionality of growth occur in the cortical plate at major sulci. Our analysis also detected directional growth asymmetry in the peri-Sylvian region and the medial frontal lobe of the fetal brain.
Year
DOI
Venue
2012
10.1016/j.neuroimage.2012.03.092
NeuroImage
Keywords
Field
DocType
Structural MRI,Fetal imaging,Tensor based morphometry,Directional growth modeling,Brain development
Brain mapping,Developmental psychology,Population,Diffusion MRI,Neuroscience,Lateralization of brain function,Tensor,Psychology,Directionality,Brain morphometry,Frontal lobe
Journal
Volume
Issue
ISSN
63
2
1053-8119
Citations 
PageRank 
References 
6
0.48
16
Authors
8
Name
Order
Citations
PageRank
Vidya Rajagopalan1271293.84
Julia Scott2182.02
Piotr A. Habas342922.70
Kio Kim412210.22
François Rousseau534622.15
Orit A. Glenn61249.68
A. James Barkovich711713.20
Colin Studholme81824241.10