Name
Abstract | ||
|---|---|---|
This paper presents a method that uses gene ontologies, together with the paradigm of relational subgroup discovery, to help find description of groups of genes differentially expressed in specific cancers. The descriptions are represented by means of relational features, extracted from gene ontology information, and are straightforwardly interpretable by the medical experts. We applied the proposed method to two known data sets: acute lymphoblastic leukemia (ALL) vs. acute myeloid leukemia and classification of fourteen types of cancer. Significant number of discovered groups of genes had a description, confirmed by the medical expert, which highlighted the underlying biological process that is responsible for distinguishing one class from the other classes. We view our methodology not just as a prototypical example of applying sophisticated machine learning algorithms to microarray data, but also as a motivation for developing more sophisticated functional annotations and ontologies, that can be processed by such learning algorithms. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1007/11875741_9 | CompLife |
Keywords | Field | DocType |
gene ontology information,relational subgroup discovery,medical expert,acute lymphoblastic leukemia,descriptive analysis,gene ontology,known data set,acute myeloid leukemia,relational feature,learning algorithm,microarray data,machine learning,feature extraction,biological process | Inductive logic programming,Ontology (information science),Descriptive statistics,Data set,Biology,Information retrieval,Gene ontology,Lymphoblastic Leukemia,Microarray analysis techniques | Conference |
Volume | ISSN | ISBN |
4216 | 0302-9743 | 3-540-45767-4 |
Citations | PageRank | References |
5 | 0.46 | 7 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Igor Trajkovski | 1 | 54 | 5.84 |
| Filip Železný | 2 | 129 | 13.09 |
| Jakub Tolar | 3 | 89 | 5.88 |
| Nada Lavrač | 4 | 989 | 72.19 |