Paper Info
Title
Localization of activated Ca2+/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation
Abstract
Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a crucial role in the induction of long-term potentiation (LTP). One form of LTP expression is thought to be the phosphorylation of glutamate receptor channels by CaMKII. Thus the localization of activated CaMKII within a spine will affect the expression of LTP. The translocation of activated CaMKII to PSD was reported. Here we investigated the localization of activated CaMKII in a model dendritic spine, and found that the diffusion of calmodulin and calcineurin but not CaMKII contribute to the localization of activated CaMKII near PSD. This will offer an additional mechanism for the localization.
Year
DOI
Venue
2004
10.1016/j.neucom.2004.01.079
Neurocomputing
Keywords
DocType
Volume
Synaptic plasticity,Spine,CaMKII,Calmodulin,Localization
Journal
58
ISSN
Citations 
PageRank 
0925-2312
0
0.34
References 
Authors
0
1
Name
Order
Citations
PageRank
Kazuhisa Ichikawa13011.02