Paper Info
Title
Using an MR imaging-guidewire as an intravascular local heating source: toward thermal enhancement of vascular gene transfection
Abstract
Heating can enhance gene transfection/expression. We developed a novel endovascular microwave heating source using an MR imaging-guidewire (MRIG) to deliver external microwave energy into the target vessels. We investigated (i) microwave power loss along differently-sized MRIGs; (ii) microwave power distribution around MRIGs; and (iii) temperature increases versus input microwave powers with MRIGs. Then, we evaluated, in vivo, the possibility of using the MR imaging/heating guidewire to generate high-resolution MR images and deliver the controlled therapeutic heat energy into the target vessel wall with histological confirmation. The results showed that the MRIG had no thermal damage to the vessel wall and can be used as an intravascular local heating device. This study has established the groundwork for further efficient management of cardiovascular atherosclerotic diseases using MRI-based vascular gene therapy.
Year
DOI
Venue
2002
10.1109/ISBI.2002.1029285
ISBI
Keywords
Field
DocType
cardiovascular atherosclerotic diseases,microwave power distribution,thermal enhancement,genetics,intravascular local heating source,mri-based vascular gene therapy,blood vessels,thermal damage,mr imaging-guidewire,histological confirmation,controlled therapeutic heat energy,biomedical mri,microwave power loss,hyperthermia,microwave heating,target vessel wall,vascular gene transfection,in vivo,cardiology,temperature control,high resolution
Mr imaging,Therapeutic Heat,Microwave,Thermal,Transfection,Computer science,Microwave power,Microwave heating,Nuclear magnetic resonance
Conference
ISBN
Citations 
PageRank 
0-7803-7584-X
0
0.34
References 
Authors
0
5
Name
Order
Citations
PageRank
Bensheng Qiu1116.59
Christopher J. Yeung200.34
Xiangying Du301.69
Ergin Atalar43913.48
Xiaoming Yang502.03