Name
Abstract | ||
|---|---|---|
AREsite is an online resource for the detailed investigation of AU-rich elements (ARE) in vertebrate mRNA 3'-untranslated regions (UTRs). AREs are one of the most prominent cis-acting regulatory elements found in 3'-UTRs of mRNAs. Various ARE-binding proteins that possess RNA stabilizing or destabilizing functions are recruited by sequence-specific motifs. Recent findings suggest an essential role of the structural mRNA context in which these sequence motifs are embedded. AREsite is the first database that allows to quantify the structuredness of ARE motif sites in terms of opening energies and accessibility probabilities. Moreover, we also provide a detailed phylogenetic analysis of ARE motifs and incorporate information about experimentally validated targets of the ARE-binding proteins TTP, HuR and Auf1. The database is publicly available at: http://rna.tbi.univie.ac.at/AREsite. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1093/nar/gkq990 | NUCLEIC ACIDS RESEARCH |
Keywords | Field | DocType |
sequence alignment,rna binding proteins,genomics,au rich element,conserved sequence | Sequence alignment,RNA,Untranslated region,Conserved sequence,Biology,Sequence motif,AU-rich element,RNA-binding protein,Three prime untranslated region,Genetics,Molecular biology,Database | Journal |
Volume | Issue | ISSN |
39 | Database-Issue | 0305-1048 |
Citations | PageRank | References |
3 | 0.48 | 6 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Andreas R. Gruber | 1 | 196 | 8.45 |
| Jörg Fallmann | 2 | 11 | 3.11 |
| Franz Kratochvill | 3 | 3 | 0.48 |
| Pavel Kovarik | 4 | 9 | 1.01 |
| Ivo L. Hofacker | 5 | 1669 | 131.57 |