Title
Order preserving clustering over multiple time course experiments
Abstract
Clustering still represents the most commonly used technique to analyze gene expression data—be it classical clustering approaches that aim at finding biologically relevant gene groups or biclustering methods that focus on identifying subset of genes that behave similarly over a subset of conditions. Usually, the measurements of different experiments are mixed together in a single gene expression matrix, where the information about which experiments belong together, e.g., in the context of a time course, is lost. This paper investigates the question of how to exploit the information about related experiments and to effectively use it in the clustering process. To this end, the idea of order preserving clusters that has been presented in [2] is extended and integrated in an evolutionary algorithm framework that allows simultaneous clustering over multiple time course experiments while keeping the distinct time series data separate.
Year
DOI
Venue
2005
10.1007/978-3-540-32003-6_4
EvoWorkshops
Keywords
Field
DocType
clustering process,time course,biclustering method,biologically relevant gene group,multiple time course experiment,gene expression data,classical clustering approach,distinct time series data,simultaneous clustering,single gene expression matrix,evolutionary algorithm,gene expression,time series data
Data mining,Fuzzy clustering,Clustering high-dimensional data,Evolutionary algorithm,Correlation clustering,Computer science,Algorithm,Constrained clustering,Biclustering,Cluster analysis,Genetic algorithm,Distributed computing
Conference
Volume
ISSN
ISBN
3449
0302-9743
3-540-25396-3
Citations 
PageRank 
References 
13
0.88
9
Authors
2
Name
Order
Citations
PageRank
a stefan bleuler a179535.85
Eckart Zitzler24678291.01