Name
Abstract | ||
|---|---|---|
It has been a practical problem for antisense researchers to select antisense oligonucleotides (asON) with a high degree of specificity, which means no or minimum cross-hybridization to other expressed genes. This paper provides a computer program, UniAntisense, which simulates hybridization of the candidate asON with every sequence in a specified UniGene database and calculates melting temperature and free energy for each hybridizable sequence to facilitate the process of selecting optimal asON. |
Year | Venue | Keywords |
|---|---|---|
2004 | METMBS '04: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MATHEMATICS AND ENGINEERING TECHNIQUES IN MEDICINE AND BIOLOGICAL SCIENCES | antisense,nucleic acid drug,nearest-neighbor Tm |
Field | DocType | Citations |
Chemistry,Oligonucleotide,Sense (molecular biology),Molecular biology | Conference | 0 |
PageRank | References | Authors |
0.34 | 0 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Yu-Cheng Huang | 1 | 15 | 2.77 |
| Yu-chih Chao | 2 | 0 | 0.34 |
| Shwu-bin Lin | 3 | 0 | 0.34 |
| Huai-Kuang Tsai | 4 | 132 | 14.33 |
| Chun-Fan Chang | 5 | 8 | 1.63 |
| Sheng-An Lee | 6 | 111 | 4.77 |
| Cheng-yan Kao | 7 | 586 | 61.50 |