Name
Title | ||
|---|---|---|
A general computational model of mitochondrial metabolism in a whole organelle scale. |
Abstract | ||
|---|---|---|
A computational tool for mitochondrial systems biology has been developed as a simulation model of E-Cell2, a publicly available simulation system. The general model consists of 58 enzymatic reactions and 117 metabolites, representing the respiratory chain, the TCA cycle, the fatty acid beta-oxidation and the inner-membrane transport system. It is based on previously published enzyme kinetics studies in the literature; we have successfully integrated and packaged them into a single large model. The model can be easily extended and modified so that mitochondrial biologists/physiologists can integrate their own models and evaluate them in the context of the whole organelle metabolism.The mitochondrial model is bundled up with E-Cell2 simulation system, which can be downloaded from http://www.e-cell.org. CD-ROMs are also available and are distributed at major conferences.All the kinetic data are available via http://www.e-cell.org |
Year | DOI | Venue |
|---|---|---|
2004 | 10.1093/bioinformatics/bth125 | Bioinformatics |
Keywords | Field | DocType |
inner-membrane transport system,single large model,general computational model,mitochondrial model,mitochondrial metabolism,e-cell2 simulation system,general model,mitochondrial systems biology,simulation model,available simulation system,own model,mitochondrial biologist,whole organelle scale,computer model,gustatory system,immunohistochemistry,neuropeptides | Simulation system,Transport system,Mitochondrion,Computer science,Systems biology,Gustatory system,Organelle,Bioinformatics | Journal |
Volume | Issue | ISSN |
20 | 11 | 1367-4803 |
Citations | PageRank | References |
4 | 0.96 | 1 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Katsuyuki Yugi | 1 | 189 | 42.63 |
| Masaru Tomita | 2 | 1009 | 180.20 |