Title
Is burst activity in cortical slices a representative model for epilepsy?
Abstract
Neocortical slices including sensory cortex of mouse were used to study cellular and network activity during bicuculline evoked seizure-like activity. The relationship between the activities of single cells and the network was quantified using entropy measures of spike trains. The network shows a large increase in synchronous burst activity during the seizure-like phase. Surprisingly, the individual cells do not seem to follow this pattern of increased synchrony. It is hypothesized that the recruitment of silent units during the seizure onset may explain this paradoxical finding. Our data agrees with recent findings in experimental seizures and intra-operative recordings in humans. (C) 2003 Elsevier Science B.V. All rights reserved.
Year
DOI
Venue
2003
10.1016/S0925-2312(02)00859-7
NEUROCOMPUTING
Keywords
Field
DocType
neural networks,life and medical sciences,computational neuro science,conferences/0202041
Sensory cortex,Neuroscience,Pattern recognition,Epilepsy,Artificial intelligence,Bicuculline,Network activity,Mathematics
Journal
Volume
Issue
ISSN
52-4
2
0925-2312
Citations 
PageRank 
References 
0
0.34
0
Authors
5
Name
Order
Citations
PageRank
Wim van Drongelen1677.91
Henner Koch200.34
Charles Marcuccilli300.34
Kurt Hecox4213.31
Jan Marino Ramirez500.34