Title
Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues.
Abstract
We have built a fiber-optic confocal reflectance microscope capable of imaging human tissues in near real time. Miniaturization of the objective lens and the mechanical components for positioning and axially scanning the objective enables the device to be used in inner organs of the human body. The lateral resolution is 2 micrometers and axial resolution is 10 micrometers. Confocal images of fixed tissue biopsies and the human lip in vivo have been obtained at 15 frames/s without any fluorescent stains. Both cell morphology and tissue architecture can be appreciated from images obtained with this microscope.
Year
DOI
Venue
2002
10.1109/TBME.2002.803524
IEEE Trans. Biomed. Engineering
Keywords
Field
DocType
human tissues,cellular biophysics,2 micron,fixed tissue biopsies,image resolution,human lip,optical fibres,medical instrumentation,fluorescence,laser reflectance,human body inner organs,cell morphology,lateral resolution,10 micron,optical microscopes,confocal images,fluorescent stains,laser applications in medicine,biological tissues,miniature objective,in vivo imaging,tissue architecture,fiber-optic confocal reflectance microscope,indexing terms,fiber optic,confocal microscopy,human body,near real time
Optical fiber,Cell morphology,Computer science,Optics,Microscope,Confocal,Miniaturization,Reflectivity,Image resolution,Preclinical imaging
Journal
Volume
Issue
ISSN
49
10
0018-9294
Citations 
PageRank 
References 
4
0.95
0
Authors
6
Name
Order
Citations
PageRank
Kung-Bin Sung152.02
Chen Liang240.95
Michael Descour340.95
Tom Collier440.95
M Follen593.65
Rebecca Richards-Kortum6225.12