Paper Info
Title
SPIKE: a database of highly curated human signaling pathways.
Abstract
The rapid accumulation of knowledge on biological signaling pathways and their regulatory mechanisms has highlighted the need for specific repositories that can store, organize and allow retrieval of pathway information in a way that will be useful for the research community. SPIKE (Signaling Pathways Integrated Knowledge Engine; http://www.cs.tau.ac.il/similar to spike/is a database for achieving this goal, containing highly curated interactions for particular human pathways, along with literature-referenced information on the nature of each interaction. To make database population and pathway comprehension straightforward, a simple yet informative data model is used, and pathways are laid out as maps that reflect the curator's understanding and make the utilization of the pathways easy. The database currently focuses primarily on pathways describing DNA damage response, cell cycle, programmed cell death and hearing related pathways. Pathways are regularly updated, and additional pathways are gradually added. The complete database and the individual maps are freely exportable in several formats. The database is accompanied by a stand-alone software tool for analysis and dynamic visualization of pathways.
Year
DOI
Venue
2011
10.1093/nar/gkq1167
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
dna damage,signaling pathway,apoptosis,cell cycle,signal transduction
Software tool,Population,Biology,Visualization,Small Molecule Pathway Database,Signal transduction,Data model,Database,Biological pathway,BioPAX : Biological Pathways Exchange
Journal
Volume
Issue
ISSN
39
SUPnan
0305-1048
Citations 
PageRank 
References 
12
0.66
10
Authors
12
Name
Order
Citations
PageRank
Arnon Paz1120.66
Zippora Brownstein2120.66
Yaara Ber3120.66
Shani Bialik4120.66
Eyal David5301.68
Dorit Sagir6120.66
Igor Ulitsky729912.96
Ran Elkon81315.22
Adi Kimchi9121.00
Karen B Avraham10201.22
Yosef Shiloh111405.63
Ron Shamir123678418.00