Paper Info
Title
Long term modulation and control of neuronal firing in excitable tissue using optogenetics
Abstract
Since the initial demonstration of nerve excitation and the subsequent action potential generation by Hodgkin and Huxley in 1952, most efforts in modulating or restoring neural activity to cure diseases or injury have concentrated on using neural interfaces for electrical stimulation with electrodes. However, it was soon appreciated that repeated chronic stimulations necessary for lasting rehabilitation could have its drawbacks. Namely, the eventual degradation of tissue and electrodes, issues of biocompatibility and immune responses to foreign objects. Nevertheless, new innovative methods are emerging which can improve the quality and duration of neural stimulations. Here we review and suggest an alternative approach to modulate activity using optogenetics in therapy.
Year
DOI
Venue
2011
10.1007/978-3-642-21344-1_28
IWINAC (1)
Keywords
Field
DocType
long term modulation,eventual degradation,neural interface,initial demonstration,neural activity,lasting rehabilitation,excitable tissue,neuronal firing,immune response,alternative approach,electrical stimulation,foreign object,neural stimulation
Deep brain stimulation,Neuroscience,Optogenetics,Computer science,Neural activity,Artificial intelligence,Multielectrode array,Stimulation,Machine learning,Hodgkin–Huxley model
Conference
Volume
ISSN
Citations 
6686
0302-9743
0
PageRank 
References 
Authors
0.34
0
3
Name
Order
Citations
PageRank
L. Humphreys100.34
J. M. Ferrández284.63
Eduardo B. Fernandez31653429.84