Name
Title | ||
|---|---|---|
Striatal dopamine D/D receptor binding in pathological gambling is correlated with mood-related impulsivity. |
Abstract | ||
|---|---|---|
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal dopamine D2/D3 receptor availability has been reported in drug addiction, and may constitute a premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess striatal dopamine D2/D3 receptor availability in PG, and its association with trait impulsivity. Males with PG (n=9) and male healthy controls (n=9) underwent [11C]-raclopride positron emission tomography imaging and completed the UPPS-P impulsivity scale. There was no significant difference between groups in striatal dopamine D2/D3 receptor availability, in contrast to previous reports in drug addiction. However, mood-related impulsivity (‘Urgency’) was negatively correlated with [11C]-raclopride binding potentials in the PG group. The absence of a group difference in striatal dopamine binding implies a distinction between behavioural addictions and drug addictions. Nevertheless, our data indicate heterogeneity in dopamine receptor availability in disordered gambling, such that individuals with high mood-related impulsivity may show differential benefits from dopamine-based medications. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2012.06.067 | NeuroImage |
Keywords | Field | DocType |
Gambling,Impulsivity,Dopamine,Neuroimaging,Addiction,Striatum | Developmental psychology,Dopamine receptor,Dopamine binding,Impulsivity,Addiction,Striatum,Psychology,Dopamine,Dopamine receptor D2,Dopamine receptor D3 | Journal |
Volume | Issue | ISSN |
63 | 1 | 1053-8119 |
Citations | PageRank | References |
4 | 0.58 | 3 |
Authors | ||
11 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Luke Clark | 1 | 4 | 0.58 |
| Paul R A Stokes | 2 | 18 | 4.12 |
| Kit Wu | 3 | 4 | 0.58 |
| Rosanna Michalczuk | 4 | 4 | 0.58 |
| Aaf Benecke | 5 | 6 | 0.95 |
| Ben J. Watson | 6 | 6 | 1.63 |
| Alice Egerton | 7 | 15 | 3.33 |
| Paola Piccini | 8 | 4 | 0.58 |
| David J. Nutt | 9 | 27 | 4.57 |
| Henrietta Bowden-Jones | 10 | 4 | 0.58 |
| Anne Lingford-Hughes | 11 | 20 | 2.72 |