Paper Info
Title
The systematic annotation of the three main GPCR families in Reactome.
Abstract
Reactome is an open-source, freely available database of human biological pathways and processes. A major goal of our work is to provide an integrated view of cellular signalling processes that spans from ligand-receptor interactions to molecular readouts at the level of metabolic and transcriptional events. To this end, we have built the first catalogue of all human G protein-coupled receptors (GPCRs) known to bind endogenous or natural ligands. The UniProt database has records for 797 proteins classified as GPCRs and sorted into families A/1, B/2 and C/3 on the basis of amino accid sequence. To these records we have added details from the IUPHAR database and our own manual curation of relevant literature to create reactions in which 563 GPCRs bind ligands and also interact with specific G-proteins to initiate signalling cascades. We believe the remaining 234 GPCRs are true orphans. The Reactome GPCR pathway can be viewed as a detailed interactive diagram and can be exported in many forms. It provides a template for the orthology-based inference of GPCR reactions for diverse model organism species, and can be overlaid with protein-protein interaction and gene expression datasets to facilitate overrepresentation studies and other forms of pathway analysis. Database URL: http://www.reactome.org
Year
DOI
Venue
2010
10.1093/database/baq018
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Keywords
Field
DocType
signal transduction,ligands
Data mining,Annotation,G protein-coupled receptor,Biology,UniProt,Orphan Nuclear Receptors,Pathway analysis,Model organism,Bioinformatics
Journal
Volume
Issue
ISSN
2010
0
1758-0463
Citations 
PageRank 
References 
2
0.68
4
Authors
7
Name
Order
Citations
PageRank
Bijay Jassal178159.93
Steven Jupe229414.30
Michael Caudy320.68
Ewan Birney42989603.10
Lincoln Stein541.04
H. Hermjakob671.15
Peter D’Eustachio7416.62