Title
Time-dependent LTD as a stability factor
Abstract
Several laboratories in studies of various brain areas have reported a dependence of long-term potentiation (LTP) and long-term depression (LTD) on the relative timing of presynaptic and postsynaptic activities. The observation that LTP occurs when presynaptic activity precedes postsynaptic activity is consistent with Hebbian ideas regarding prediction. However, the computational role of LTD under the opposite condition (postsynaptic precedes presynaptic) does not find an easy explanation. Here, we propose that this form of LTD stabilizes learning of temporal associations. This conjecture is demonstrated in two tasks, and compared with another possible stabilizing mechanism, weight decay. (C) 2001 Elsevier Science B.V. All rights reserved.
Year
DOI
Venue
2001
10.1016/S0925-2312(01)00350-2
NEUROCOMPUTING
Keywords
Field
DocType
long-term depression (LTD),prediction,spike-timing plasticity
Long-term potentiation,Neuroscience,Pattern recognition,Postsynaptic potential,Weight decay,Hebbian theory,Artificial intelligence,Stability factor,Spike-timing-dependent plasticity,Mathematics
Journal
Volume
Issue
ISSN
38
1-4
0925-2312
Citations 
PageRank 
References 
0
0.34
0
Authors
2
Name
Order
Citations
PageRank
Paul W. Munro19913.86
Gerardina Hernández200.34