Title
IMENSE: An e-infrastructure environment for patient specific multiscale data integration, modelling and clinical treatment.
Abstract
Secure access to patient data and analysis tools to run on that data will revolutionize the treatment of a wide range of diseases, by using advanced simulation techniques to underpin the clinical decision making process. To achieve these goals, suitable e-Science infrastructures are required to allow clinicians and researchers to trivially access data and launch simulations. In this paper we describe the open source Individualized MEdiciNe Simulation Environment (IMENSE), which provides a platform to securely manage clinical data, and to perform wide ranging analysis on that data, ultimately with the intention of enhancing clinical decision making with direct impact on patient health care. We motivate the design decisions taken in the development of the IMENSE system by considering the needs of researchers in the ContraCancrum project, which provides a paradigmatic case in which clinicians and researchers require coordinated access to data and simulation tools. We show how the modular nature of the IMENSE system makes it applicable to a wide range of biomedical computing scenarios, from within a single hospital to major international research projects. (C) 2011 Elsevier B.V. All rights reserved.
Year
DOI
Venue
2012
10.1016/j.jocs.2011.07.001
Journal of Computational Science
Keywords
Field
DocType
Clinical decision support,Electronic health records,Virtual Physiological Human,Medical data management
Health care,Data science,Data integration,Clinical treatment,Computer science,Knowledge management,Virtual Physiological Human,Theoretical computer science,Modular design,Clinical decision support system,Data access,Personalized medicine
Journal
Volume
Issue
ISSN
3
5
1877-7503
Citations 
PageRank 
References 
3
0.42
18
Authors
8
Name
Order
Citations
PageRank
Stefan J. Zasada112912.79
Tao Wang230.42
Ali Nasrat Haidar3716.03
Enjie Liu410018.25
Norbert Graf58717.28
Gordon Clapworthy635054.23
Steven Manos7263.77
Peter V. Coveney820632.82