Name
Abstract | ||
|---|---|---|
Clinical research includes a wide range of study designs from focused observational studies to complex interventional studies with multiple study arms, treatment and assessment events, and specimen procurement procedures. Participant characteristics from case report forms need to be integrated with molecular characteristics from mechanistic experiments on procured specimens. In order to capture and manage this diverse array of data, we have developed the Ontology-Based eXtensible data model (OBX) to serve as a framework for clinical research data in the Immunology Database and Analysis Portal (ImmPort). By designing OBX around the logical structure of the Basic Formal Ontology (BFO) and the Ontology for Biomedical Investigations (OBI), we have found that a relatively simple conceptual model can represent the relatively complex domain of clinical research. In addition, the common framework provided by BFO makes it straightforward to develop data dictionaries based on reference and application ontologies from the OBO Foundry. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1016/j.jbi.2010.05.001 | Journal of Biomedical Informatics |
Keywords | Field | DocType |
biomaterial transformation,ontology-based extensible data model,common framework,multiple study arm,clinical research,simple conceptual model,conceptual model,observational study,clinical trials,complex interventional study,clinical research databases,basic formal ontology,clinical research data,data transformation,ontology,assay,complex domain,ontology-based framework,database management systems,data model,clinical trial,computational biology,medical informatics,biomedical research,study design | Data science,Ontology,Data mining,Computer science,Ontology (information science),Ontology for Biomedical Investigations,Information retrieval,Open Biomedical Ontologies,Data dictionary,Basic Formal Ontology,OBO Foundry,Data model,Database | Journal |
Volume | Issue | ISSN |
44 | 1 | Journal of Biomedical Informatics |
Citations | PageRank | References |
10 | 1.25 | 2 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Y Megan Kong | 1 | 17 | 2.06 |
| Carl Dahlke | 2 | 10 | 1.25 |
| Qun Xiang | 3 | 10 | 1.25 |
| Yu Qian | 4 | 28 | 2.98 |
| David R Karp | 5 | 13 | 1.67 |
| Richard H. Scheuermann | 6 | 258 | 23.91 |