Title | ||
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Calcium oscillations and ectopic beats in virtual ventricular myocytes and tissues: bifurcations, autorhythmicity and propagation |
Abstract | ||
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One mechanism for the onset of arrhythmias is abnormal impulse initiation such as ventricular ectopic beats. These may be caused by abnormal calcium (Ca2+) cycling. The Luo-Rudy model was used to simulate the dynamics of intracellular Ca2+ ([Ca2+]i) handling and the initiation of ectopic beats in virtual ventricular myocytes and tissues. [Ca2+]i in the reduced Ca2+ handling equations settles to a steady state at low levels of intracellular sodium ([Na+]i), but oscillates when [Na+]i is increased. These oscillations emerge through a homoclinic bifurcation. In the whole cell, Ca2+ overload, brought about by inhibition of the sodium-potassium pump and elevated [Na+]i, can cause autorhythmic depolarisations. These oscillations interact with membrane currents to cause action potentials that propagate through one dimensional virtual tissue strands and two dimensional anisotropic virtual tissue sheets. |
Year | DOI | Venue |
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2005 | 10.1007/11494621_31 | FIMH |
Keywords | Field | DocType |
abnormal impulse initiation,intracellular sodium,ectopic beat,virtual ventricular myocytes,dimensional anisotropic virtual tissue,intracellular ca2,reduced ca2,calcium oscillation,dimensional virtual tissue strand,abnormal calcium,oscillations interact,steady state,oscillations,potassium,action potential | Myocyte,Homoclinic bifurcation,Calcium,Biophysics,Internal medicine,Cardiology,Chemistry,Intracellular,Endoplasmic reticulum,Sodium,Cardiac action potential,Ectopic beat | Conference |
Volume | ISSN | ISBN |
3504 | 0302-9743 | 3-540-26161-3 |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
2 |
Name | Order | Citations | PageRank |
---|---|---|---|
Alan P. Benson | 1 | 4 | 5.14 |
Arun V. Holden | 2 | 52 | 20.71 |