Paper Info
Title
Age-related cognitive gains are mediated by the effects of white matter development on brain network integration.
Abstract
A fundamental, yet rarely tested premise of developmental cognitive neuroscience is that changes in brain activity and improvements in behavioral control across adolescent development are related to brain maturational factors that shape a more efficient, highly-interconnected brain in adulthood. We present the first multimodal neuroimaging study to empirically demonstrate that maturation of executive cognitive ability is directly associated with the relationship of white matter development and age-related changes in neural network functional integration. In this study, we identified specific white matter regions whose maturation across adolescence appears to reduce reliance on local processing in brain regions recruited for conscious, deliberate cognitive control in favor of a more widely distributed profile of functionally-integrated brain activity. Greater white matter coherence with age was associated with both increases and decreases in functional connectivity within task-engaged functional circuits. Importantly, these associations between white matter development and brain system functional integration were related to behavioral performance on tests of response inhibition, demonstrating their importance in the maturation of optimal cognitive control.
Year
DOI
Venue
2009
10.1016/j.neuroimage.2009.06.065
NeuroImage
Keywords
Field
DocType
Connectivity,Diffusion tensor imaging,Network,Response inhibition,Development,Adolescent
Developmental cognitive neuroscience,Brain mapping,Developmental psychology,Diffusion MRI,Neuroscience,White matter,Cognitive psychology,Psychology,Brain activity and meditation,Young adult,Neuroimaging,Cognition
Journal
Volume
Issue
ISSN
48
4
1053-8119
Citations 
PageRank 
References 
5
0.54
13
Authors
4
Name
Order
Citations
PageRank
Michael C. Stevens121919.57
Pawel Skudlarski21309.62
Godfrey Pearlson353038.30
Vince D Calhoun42769268.91