Name
Title | ||
|---|---|---|
A model for drosophila melanogaster development from a single cell to stripe pattern formation |
Abstract | ||
|---|---|---|
The development of multicellular organisms, from the early forms of zygote, involves a range of phenomena that control cell growth and differentiation, making the overall process of morphogenesis highly complex. A well studied example of such a huge phenomenon is given by Drosophila Melanogaster morphogenesis that has been object of several models, whose main goal was to investigate the mechanisms involved in the spatial and temporal evolution of the patterning process, namely gene regulatory network, mor-phogen diffusion, synthesis and degradation. In this paper we present a model of Drosophila development that considers also nuclear division and movements as basic morphogenetic mechanisms. The model is run on top of a prototype simulator which is based on a variation of an existing SSA (Stochastic Simulation Algorithm), tailored to the specific features of embryo development, including dynamicity in the topology of compartment network. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1145/2245276.2231999 | SAC |
Keywords | Field | DocType |
basic morphogenetic mechanism,embryo development,gene regulatory network,single cell,control cell growth,stochastic simulation algorithm,drosophila development,pattern formation,drosophila melanogaster development,drosophila melanogaster morphogenesis,overall process,patterning process,compartment network,computational biology,cell growth,cellular model,stochastic simulation | Stochastic simulation,Multicellular organism,Zygote,Biological system,Computer science,Pattern formation,Cell,Bioinformatics,Gene regulatory network,Drosophila melanogaster,Morphogenesis | Conference |
Citations | PageRank | References |
2 | 0.38 | 7 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sara Montagna | 1 | 345 | 23.45 |
| Danilo Pianini | 2 | 374 | 27.75 |
| Mirko Viroli | 3 | 2278 | 156.77 |