Title
Design and validation of automated femoral bone morphology measurements in cerebral palsy.
Abstract
Accurate quantification of bone morphology is important for monitoring the progress of bony deformation in patients with cerebral palsy. The purpose of the study was to develop an automatic bone morphology measurement method using one or two radiographs. The study focused on four morphologic measurements-neck-shaft angle, femoral anteversion, shaft bowing angle, and neck length. Fifty-four three-dimensional (3D) geometrical femur models were generated from the computed tomography (CT) of cerebral palsy patients. Principal component analysis was performed on the combined data of geometrical femur models and manual measurements of the four morphologic measurements to generate a statistical femur model. The 3D-2D registration of the statistical femur model for radiography computes four morphological measurements of the femur in the radiographs automatically. The prediction performance was tested here by means of leave-one-out cross-validation and was quantified by the intraclass correlation coefficient (ICC) and by measuring the absolute differences between automatic prediction from two radiographs and manual measurements using original CT images. For the neck-shaft angle, femoral anteversion, shaft bowing angle, and neck length, the ICCs were 0.812, 0.960, 0.834, and 0.750, respectively, and the mean absolute differences were 2.52°, 2.85°, 0.92°, and 1.88 mm, respectively. Four important dimensions of the femur could be predicted from two views with very good agreement with manual measurements from CT and hip radiographs. The proposed method can help young patients avoid instances of large radiation exposure from CT, and their femoral deformities can be quantified robustly and effectively from one or two radiograph(s).
Year
DOI
Venue
2014
10.1007/s10278-013-9643-2
J. Digital Imaging
Keywords
Field
DocType
Femoral morphology, Cerebral palsy, Automatic morphology quantification, Statistical shape model
Computer science,Cerebral palsy,Femur,Radiography,Computed tomography,Radiology,Radiation exposure,Intraclass correlation
Journal
Volume
Issue
ISSN
27
2
1618-727X
Citations 
PageRank 
References 
0
0.34
6
Authors
5
Name
Order
Citations
PageRank
Noyeol Park100.34
Jehee Lee21912118.33
Kihyuk Sung3163.22
Moon Seok Park4342.51
Seungbum Koo5262.27