Name
Abstract | ||
|---|---|---|
p53 is a paramount protein in cancer studies. p53-Mdm2 interaction is the core regulation for most activities of p53 protein-related networks. In this paper a new mathematical model is proposed to reveal the mechanisms existing in this core regulation. This model is mainly based on the recent biological findings, as well as few reasonable hypotheses and approximations. The performance is in good accord with the experimental phenomenon in the literature. And a new threshold mechanism is also discussed, which gives more insights for experimental design and validation. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1109/ICSMC.2008.4811537 | SMC |
Keywords | Field | DocType |
p53-mdm2 interaction,mathematical model,cellular biophysics,dna damage,systems biology,protein,p53-mdm2 core regulation,proteins,molecular biophysics,cancer,bifurcation analysis,cellular pathways,tumours,tumour suppressor,ionizing radiation,bifurcation,oscillators,asynchronous transfer mode,experimental design,degradation,system biology | Cellular biophysics,Bifurcation analysis,Computer science,Biochemical engineering,Systems biology,Artificial intelligence,Bioinformatics,Machine learning | Conference |
ISSN | ISBN | Citations |
1062-922X E-ISBN : 978-1-4244-2384-2 | 978-1-4244-2384-2 | 0 |
PageRank | References | Authors |
0.34 | 0 | 2 |