Title
PconsC: combination of direct information methods and alignments improves contact prediction.
Abstract
Recently, several new contact prediction methods have been published. They use (i) large sets of multiple aligned sequences and (ii) assume that correlations between columns in these alignments can be the results of indirect interaction. These methods are clearly superior to earlier methods when it comes to predicting contacts in proteins. Here, we demonstrate that combining predictions from two prediction methods, PSICOV and plmDCA, and two alignment methods, HHblits and jackhmmer at four different e-value cut-offs, provides a relative improvement of 20% in comparison with the best single method, exceeding 70% correct predictions for one contact prediction per residue.
Year
DOI
Venue
2013
10.1093/bioinformatics/btt259
BIOINFORMATICS
Keywords
Field
DocType
biological sciences
Data mining,Source code,Computer science,Bioinformatics
Journal
Volume
Issue
ISSN
29
14
1367-4803
Citations 
PageRank 
References 
23
1.37
4
Authors
3
Name
Order
Citations
PageRank
Marcin J. Skwark11448.76
Abbi Abdel-Rehim2231.37
Arne Elofsson363356.98