Title
Altered working memory process in the manganese-exposed brain.
Abstract
Chronic manganese (Mn) exposure often leads to impairments in fine motor and cognitive functions, particularly memory. However, the neural correlates of Mn-induced alterations in memory remain unclear. In the present study, we performed functional MRI (fMRI) with 2-back memory tests to assess the neural correlates of Mn-induced memory impairment in response to subclinical dysfunction in the working memory networks in welders exposed to Mn for extended periods of time. Within-group and between-group analyses revealed that brain activity in working memory networks was increased in welders with chronic Mn exposure during the 2-back verbal working memory task compared to healthy control individuals. Therefore, our fMRI findings indicate that welders might require more neural resources in working memory networks to compensate for subtle deficits in working memory and altered working memory processes, even if they performed the tasks at the same level as healthy control individuals.
Year
DOI
Venue
2010
10.1016/j.neuroimage.2010.07.001
NeuroImage
Keywords
Field
DocType
Manganese (Mn),Functional magnetic resonance imaging (fMRI),Welder,Memory deficit
Neural correlates of consciousness,Developmental psychology,Neuroscience,Healthy control,Working memory,Psychology,Cognitive psychology,Brain activity and meditation,Subclinical infection,Cognition,Methods used to study memory
Journal
Volume
Issue
ISSN
53
4
1053-8119
Citations 
PageRank 
References 
0
0.34
3
Authors
12
Name
Order
Citations
PageRank
Yongmin Chang100.34
Jaejun Lee2105.69
Jee-Hye Seo300.34
Hui-Jin Song400.68
Joohyun Kim529222.75
Sung-Jin Bae600.34
Joon-Ho Ahn700.34
Sin-Jae Park800.34
Kyoung Sook Jeong900.34
Young Joo Kwon1000.34
Suk Hwan Kim1100.34
Yangho Kim1200.34