Paper Info
Title
An Accurate and Robust Missing Value Estimation for Microarray Data: Least Absolute Deviation Imputation
Abstract
Microarray experiments often produce missing expression values due to various reasons. Accurate and robust estimation methods of missing values are needed since many algorithms and statistical analysis require a complete data set. In this paper, novel imputation methods based on least absolute deviation estimate, referred to as LADimpute, are proposed to estimate missing entries in microarray data. The proposed LADimpute method takes into consideration the local similarity structures in addition to employment of least absolute deviation estimate. Once those genes similar to the target gene with missing values are selected based on some metric, all missing values in the target gene can be estimated by the linear combination of the similar genes simultaneously. In our experiments, the proposed LADimpute method exhibits its accurate and robust performance when compared to other methods over different datasets, changing missing rates and various noise levels.
Year
DOI
Venue
2006
10.1109/ICMLA.2006.11
Orlando, FL
Keywords
Field
DocType
proposed ladimpute method,absolute deviation imputation,target gene,complete data,missing expression,novel imputation method,missing value,missing rate,absolute deviation estimate,missing entry,microarray data,robust missing value estimation,robust estimator,least absolute deviation,data analysis,genetics,missing values,statistical analysis
Linear combination,Pattern recognition,Computer science,Least absolute deviations,Microarray analysis techniques,Artificial intelligence,Missing data,Imputation (statistics),Statistical analysis
Conference
ISBN
Citations 
PageRank 
0-7695-2735-3
0
0.34
References 
Authors
4
2
Name
Order
Citations
PageRank
Cao, Y.100.34
Kim Leng Poh2627.36