Paper Info
Title
Slimfinder: A Web Server To Find Novel, Significantly Over-Represented, Short Protein Motifs
Abstract
Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein-protein interactions. The Short, Linear Motif Finder (SLiMFinder) web server is a de novo motif discovery tool that identifies statistically over-represented motifs in a set of protein sequences, accounting for the evolutionary relationships between them. Motifs are returned with an intuitive P-value that greatly reduces the problem of false positives and is accessible to biologists of all disciplines. Input can be uploaded by the user or extracted directly from UniProt. Numerous masking options give the user great control over the contextual information to be included in the analyses. The SLiMFinder server combines these with user-friendly output and visualizations of motif context to allow the user to quickly gain insight into the validity of a putatively functional motif. These visualizations include alignments of motif occurrences, alignments of motifs and their homologues and a visual schematic of the top-ranked motifs. Returned motifs can also be compared with known SLiMs from the literature using CompariMotif. All results are available for download. The SLiMFinder server is available at: http://bioware.ucd.ie/slimfinder.html.
Year
DOI
Venue
2010
10.1093/nar/gkq440
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
protein motif,protein protein interaction,protein protein interactions
Eukaryotic Linear Motif resource,Short linear motif,Biology,UniProt,Sequence motif,Motif (music),Structural motif,Computational biology,Bioinformatics,Genetics,Web server,Multiple EM for Motif Elicitation
Journal
Volume
Issue
ISSN
38
Web-Server-Issue
0305-1048
Citations 
PageRank 
References 
12
0.75
15
Authors
4
Name
Order
Citations
PageRank
Norman E. Davey122816.61
Niall J. Haslam2734.91
Denis C. Shields315820.92
Richard J. Edwards41379.93