Name
Title | ||
|---|---|---|
Computational Modeling For The Activation Cycle Of G-Proteins By G-Protein-Coupled Receptors |
Abstract | ||
|---|---|---|
In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-proteincoupled receptors (GPCRs) as a driving example. Starting from an existing Ordinary Differential Equations (ODEs) model, we implement the G-protein cycle in the stochastic Pi-calculus using SPiM, as Petri-nets using Cell Illustrator, in the Kappa Language using Cellucidate, and in BioPEPA using the Bio-PEPA eclipse plug in. We also provide a high-level notation to abstract away from communication primitives that may be unfamiliar to the average biologist, and we show how to translate high-level programs into stochastic Pi-calculus processes and chemical reactions. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.4204/EPTCS.40.4 | ELECTRONIC PROCEEDINGS IN THEORETICAL COMPUTER SCIENCE |
Keywords | Field | DocType |
g protein coupled receptor,ordinary differential equation,chemical reaction,computer model,g protein,quantitative method,petri net | Notation,Ordinary differential equation,G protein-coupled receptor,Computer science,G protein,Theoretical computer science,Cell signaling,Ode,Eclipse plug in | Journal |
Issue | ISSN | Citations |
40 | 2075-2180 | 7 |
PageRank | References | Authors |
0.58 | 10 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Yifei Bao | 1 | 14 | 1.52 |
| Adriana B. Compagnoni | 2 | 62 | 7.16 |
| Joseph Glavy | 3 | 7 | 0.58 |
| Tommy White | 4 | 7 | 0.58 |