Name
Title | ||
|---|---|---|
Spatio-temporal filtering properties of a dendritic cable with active spines: A modeling study in the spike-diffuse-spike framework. |
Abstract | ||
|---|---|---|
Abstract The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modeled with a simple integrate-and-fire process, whilst communication be- tween spines is mediated by the cable equation. In this paper we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded,on a simple one- dimensional cable. In the first instance this system is shown to support saltatory waves with the same qualitative features as those observed in a model with Hodgkin-Huxley kinetics in the spine-head. Moreover, there is excellent agreement with the analytically calculated speed for a solitary saltatory pulse. Upon driving the system with time-varying external input we find that the distribution of spines can play a crucial role in determining spatio-temporal filtering properties. In particular, the SDS model in response to periodic pulse train shows a positive correlation between spine density and low-pass temporal filtering that is consistent with the experimental results of Rose and Fortune [1999, ‘Mechanisms for generating temporal filters in the electrosensory sys- tem’. The Journal of Experimental Biology 202, 1281–1289]. Further, we demonstrate the robustness of observed wave properties to natural sources of noise that arise both in the cable and the spine-head, and highlight the possibility of purely noise induced waves and coherent oscillations. spike-diffuse-spike, dendritic spines, filtering, noise |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1007/s10827-006-8776-4 | Journal of Computational Neuroscience |
Keywords | Field | DocType |
Spike-diffuse-spike,Dendritic spines,Filtering,Noise | Oscillation,Dendritic spine,Biological system,Simulation,Control theory,Filter (signal processing),Pulse wave,Robustness (computer science),Pulse (signal processing),Cable theory,Periodic graph (geometry),Mathematics | Journal |
Volume | Issue | ISSN |
21 | 3 | 0929-5313 |
Citations | PageRank | References |
5 | 0.99 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Yulia Timofeeva | 1 | 10 | 2.61 |
| Gabriel J. Lord | 2 | 33 | 12.31 |
| Stephen Coombes | 3 | 184 | 18.30 |