Title | ||
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Movement-related desynchronization-synchronization (ERD/ERS) in patients with Unverricht-Lundborg disease. |
Abstract | ||
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We studied changes in event-related desynchronization/synchronization (ERD/ERS) patterns in patients with Unverricht–Lundborg disease (ULD), presenting with prominent action myoclonus. We analyzed the movement-related ERD/ERS in α and β frequency bands in 15 patients using self-paced finger extension as a motor paradigm and we compared the results with those obtained in 12 healthy volunteers. In all ULD patients, α- and β-ERD regularly occurred with onset and location similar to that found in healthy controls, but the desynchronization of α activity was significantly greater than in controls (C3: −64.4±9.8% vs. −49.7±14.8%; p=0.004). Moreover, in the patients, both α- and β-ERD spread toward frontal electrodes. In controls, the post-movement β-ERS regularly occurred; it was absent in eight patients with severe action myoclonus, while, in seven patients with mild or moderate myoclonus, the β-peak was significantly smaller with respect to that measured in controls (55.6±15.1% vs. 153.9±99.8%, p=0.006). The failure of β-ERS well-correlated with motor impairment resulting from action myoclonus, whereas SSEPs and long-loop reflexes performed to detect signs of cortical hyperexcitability showed inconsistent changes. In ULD patients, ERD/ERS changes indicate an increased activation of motor cortex during movement planning and a great reduction of post-excitatory inhibition of motor cortex. The changes involving β-ERS had a significant relationship with the functional disability in individual patients and might play a pathogenic role in the motor dysfunction. |
Year | DOI | Venue |
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2006 | 10.1016/j.neuroimage.2006.06.036 | NeuroImage |
Keywords | Field | DocType |
Action myoclonus,ERD/ERS,EEG,Progressive myoclonus epilepsies | Myoclonus,Motor impairment,Developmental psychology,Action myoclonus,Psychology,Reflex,Movement planning,Motor cortex,Electroencephalography,Unverricht–Lundborg disease | Journal |
Volume | Issue | ISSN |
33 | 1 | 1053-8119 |
Citations | PageRank | References |
1 | 0.43 | 0 |
Authors | ||
8 |
Name | Order | Citations | PageRank |
---|---|---|---|
E Visani | 1 | 1 | 0.43 |
P Agazzi | 2 | 1 | 0.43 |
L Canafoglia | 3 | 1 | 0.43 |
F Panzica | 4 | 1 | 0.43 |
C Ciano | 5 | 1 | 0.43 |
V Scaioli | 6 | 1 | 0.43 |
G Avanzini | 7 | 1 | 0.43 |
S Franceschetti | 8 | 1 | 0.43 |