Title
Bayesian model comparison in nonlinear bold fmri hemodynamics
Abstract
Nonlinear hemodynamic models express the BOLD (blood oxygenation level dependent) signal as a nonlinear, parametric functional of the temporal sequence of local neural activity. Several models have been proposed for both the neural activity and the hemodynamics. We compare two such combined models: the original balloon model with a square-pulse neural model (Friston, Mechelli, Turner, & Price, 2000) and an extended balloon model with a more sophisticated neural model (Buxton, Uludag, Dubowitz, & Liu, 2004). We learn the parameters of both models using a Bayesian approach, where the distribution of the parameters conditioned on the data is estimated using Markov chain Monte Carlo techniques. Using a split-half resampling procedure (Strother, Anderson, & Hansen, 2002), we compare the generalization abilities of the models as well as their reproducibility, for both synthetic and real data, recorded from two different visual stimulation paradigms. The results show that the simple model is the better one for these data.
Year
DOI
Venue
2008
10.1162/neco.2007.07-06-282
Neural Computation
Keywords
Field
DocType
bayesian approach,markov chain monte carlo
Bayesian inference,Pattern recognition,Markov chain Monte Carlo,Computer science,Markov chain,Models of neural computation,Parametric statistics,Artificial intelligence,Artificial neural network,Resampling,Machine learning,Bayesian probability
Journal
Volume
Issue
ISSN
20
3
0899-7667
Citations 
PageRank 
References 
5
0.60
5
Authors
3
Name
Order
Citations
PageRank
Daniel J. Jacobsen170.97
Lars Kai Hansen22776341.03
Kristoffer Hougaard Madsen314518.74