Paper Info
Title
Effects Of Severing The Corpus Callosum On Electrical And Bold Functional Connectivity And Spontaneous Dynamic Activity In The Rat Brain
Abstract
Functional networks, defined by synchronous spontaneous blood oxygenation level-dependent (BOLD) oscillations between spatially distinct brain regions, appear to be essential to brain function and have been implicated in disease states, cognitive capacity, and sensing and motor processes. While the topographical extent and behavioral function of these networks has been extensively investigated, the neural functions that create and maintain these synchronizations remain mysterious. In this work callosotomized rodents are examined, providing a unique platform for evaluating the influence of structural connectivity via the corpus callosum on bilateral resting state functional connectivity. Two experimental groups were assessed, a full callosotomy group, in which the corpus callosum was completely sectioned, and a sham callosotomy group, in which the gray matter was sectioned but the corpus callosum remained intact. Results indicated a significant reduction in interhemispheric connectivity in the full callosotomy group as compared with the sham group in primary somatosensory cortex and caudate-putamen regions. Similarly, electrophysiology revealed significantly reduced bilateral correlation in band limited power. Bilateral gamma Band-limited power connectivity was most strongly affected by the full callosotomy procedure. This work represents a robust finding indicating the corpus callosum's influence on maintaining integrity in bilateral functional networks; further, functional magnetic resonance imaging (fMRI) and electrophysiological connectivity share a similar decrease in connectivity as a result of the callosotomy, suggesting that fMR-Imeasured functional connectivity reflects underlying changes in large-scale coordinated electrical activity. Finally, spatiotemporal dynamic patterns were evaluated in both groups; the full callosotomy rodents displayed a striking loss of bilaterally synchronous propagating waves of cortical activity.
Year
DOI
Venue
2014
10.1089/brain.2013.0167
BRAIN CONNECTIVITY
Keywords
Field
DocType
band limited power, callosotomy, electrophysiology, fMRI, functional connectivity, rat, spatiotemporal dynamic pattern
Caudate nucleus,Brain mapping,Putamen,Neuroscience,Anatomy,Nerve net,Resting state fMRI,Somatosensory system,Corpus callosum,Medicine,Electrophysiology
Journal
Volume
Issue
ISSN
4
1
2158-0014
Citations 
PageRank 
References 
4
0.38
13
Authors
4
Name
Order
Citations
PageRank
Matthew Evan Magnuson1843.39
Garth John Thompson21558.55
Wen-Ju Pan31709.64
Shella D. Keilholz453325.92