Title
A Genetic Algorithm for Inferring Pseudoknotted RNA Structures from Sequence Data
Abstract
Pseudoknotted RNA structures are much more difficult to predict than non-pseudoknotted RNA structures both from the computational viewpoint and from the practical viewpoint. This is in part due to the unavailability of an exact energy model for pseudoknots, structural complexity of pseudoknots, and to the high time complexity of predicting algorithms. Therefore, existing approaches to predicting pseudoknotted RNA structures mostly focus on so-called H-type pseudoknots of small RNAs. We have developed a heuristic energy model and genetic algorithm for predicting RNA structures with various types of pseudoknots, including H-type pseudoknots. This paper analyzes the predictions by a genetic algorithm and compares the predictions to those by a dynamic programming algorithm.
Year
DOI
Venue
2003
10.1007/978-3-540-39644-4_31
LECTURE NOTES IN ARTIFICIAL INTELLIGENCE
Keywords
DocType
Volume
knowledge discovery,genetic algorithm,rna,artificial intelligence,dynamic programming,time complexity,data structure
Conference
2843
ISSN
Citations 
PageRank 
0302-9743
0
0.34
References 
Authors
10
2
Name
Order
Citations
PageRank
DongKyu Lee184.79
Kyungsook Han234349.98