Name
Title | ||
|---|---|---|
Systemic properties of ensembles of metabolic networks: application of graphical and statistical methods to simple unbranched pathways. |
Abstract | ||
|---|---|---|
Motivation: Mathematical models are the only realistic method for representing the integrated dynamic behavior of complex biochemical networks. However it is difficult to obtain a consistent set of values for the parameters that characterize such a model. Even when a set of parameter values exists, the accuracy of the individual values is questionable. Therefore, we were motivated to explore statistical techniques for analyzing the properties of a given model when knowledge of the actual parameter values is lacking. Results: The graphical and statistical methods presented in the previous paper are applied here to simple unbranched biosynthetic pathways subject to control by feedback inhibition. We represent these pathways within a canonical nonlinear formalism that provides a regular structure that is convenient for randomly sampling the parameter space. After constructing a large ensemble of randomly generated sets of parameter values, the structural and behavioral properties of the model with these parameter sets are examined statistically and classified The results of our analysis demonstrate that certain properties of these systems are strongly correlated thereby revealing aspects of organization that are highly probable independent of selection. Finally, we show how specification of a given behavior affects the distribution of acceptable parameter values. |
Year | DOI | Venue |
|---|---|---|
2000 | 10.1093/bioinformatics/16.6.534 | BIOINFORMATICS |
Keywords | Field | DocType |
metabolic network,parameter space,mathematical model | Data mining,Nonlinear system,Biological system,Computer science,Parameter space,Behavioral analysis,Feedback inhibition,Artificial intelligence,Sampling (statistics),Formalism (philosophy),Mathematical model,Statistical analysis | Journal |
Volume | Issue | ISSN |
16 | 6 | 1367-4803 |
Citations | PageRank | References |
8 | 6.87 | 1 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Rui Alves | 1 | 196 | 32.99 |
| M A Savageau | 2 | 31 | 20.68 |