Paper Info
Title
Mathematical Modeling Of Cardiac Electro-Mechanics: From Protein To Organ
Abstract
Mathematical models of cardiac anatomy and physics provide information, which help to understand structure and behavior of the heart. Miscellaneous cardiac phenomena can only be adequately described by combination of models representing different aspects or levels of detail. Coupling of these models necessitates the definition of appropriate interfaces. Adequateness and efficiency of interfaces is crucial for efficient application of the combined models.In this work an integrated model is presented consisting of several models interconnected by interfaces. The integrated model allows the reconstruction of macroscopic electro-mechanical processes in the heart. The model comprises a three-dimensional are of left ventricular anatomy represented as truncated ellipsoid. The integrated model includes electrophysiological, tension development and elastomechanical models of myocardium at levels of single cell, proteins, and tissue patches, respectively.The model is exemplified by simulations of extracorporated left ventricle of small mammals. These simulations yield temporal distributions of electrophysiological parameters as well as descriptions of electrical propagation and mechanical deformation. The simulations show characteristic macroscopic ventricular function resulting from the interplay between cellular electrophysiology, electrical excitation propagation, tension development, and mechanical deformation.
Year
DOI
Venue
2003
10.1142/S0218127403008910
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
Keywords
DocType
Volume
cardiac electro-mechanics, electro-mechanical modeling, mathematical modeling, finite element method
Journal
13
Issue
ISSN
Citations 
12
0218-1274
2
PageRank 
References 
Authors
0.66
3
4
Name
Order
Citations
PageRank
Frank B. Sachse16621.58
Gunnar Seemann221248.50
Matthias B. Mohr351.80
Arun V. Holden45220.71