Paper Info
Title
Accurate reconstruction of temporal correlation for neuronal sources using the enhanced dual-core MEG beamformer.
Abstract
Beamformer spatial filters are commonly used to explore the active neuronal sources underlying magnetoencephalography (MEG) recordings at low signal-to-noise ratio (SNR). Conventional beamformer techniques are successful in localizing uncorrelated neuronal sources under poor SNR conditions. However, the spatial and temporal features from conventional beamformer reconstructions suffer when sources are correlated, which is a common and important property of real neuronal networks. Dual-beamformer techniques, originally developed by Brookes et al. to deal with this limitation, successfully localize highly-correlated sources and determine their orientations and weightings, but their performance degrades at low correlations. They also lack the capability to produce individual time courses and therefore cannot quantify source correlation. In this paper, we present an enhanced formulation of our earlier dual-core beamformer (DCBF) approach that reconstructs individual source time courses and their correlations. Through computer simulations, we show that the enhanced DCBF (eDCBF) consistently and accurately models dual-source activity regardless of the correlation strength. Simulations also show that a multi-core extension of eDCBF effectively handles the presence of additional correlated sources. In a human auditory task, we further demonstrate that eDCBF accurately reconstructs left and right auditory temporal responses and their correlations. Spatial resolution and source localization strategies corresponding to different measures within the eDCBF framework are also discussed. In summary, eDCBF accurately reconstructs source spatio-temporal behavior, providing a means for characterizing complex neuronal networks and their communication.
Year
DOI
Venue
2011
10.1016/j.neuroimage.2011.03.042
NeuroImage
Keywords
Field
DocType
computer simulation,magnetoencephalography,spatial resolution,spatial filtering,signal to noise ratio,neuronal network
Computer science,Uncorrelated,Speech recognition,Correlation,Source localization,Image resolution,Magnetoencephalography
Journal
Volume
Issue
ISSN
56
4
1053-8119
Citations 
PageRank 
References 
8
0.62
12
Authors
10
Name
Order
Citations
PageRank
Mithun Diwakar1382.63
Omer Tal2803.07
Thomas T Liu3102276.03
Deborah L Harrington4807.10
Ramesh Srinivasan5819.33
Laura Muzzatti6291.67
Tao Song716916.72
Rebecca J Theilmann8393.38
Roland R Lee911610.09
Ming-Xiong Huang1015411.92